United States National Maritime Day (It is observed on May 22, the date in 1819 that the American steamship Savannah set sail from Savannah, Georgia on the first ever transoceanic voyage under steam power.)
World Goth Day (The Official World Goth Day site defines it as "a day where the goth scene gets to celebrate its own being, and an opportunity to make its presence known to the rest of the world.")
In 2018 - scientists from Purdue University and the Chinese Academy of Sciences report the use of CRISPR/Cas9 to develop a variety of rice producing 25-31% more grain than traditional breeding methods.
2015 – The Republic of Ireland becomes the first nation in the world to legalize gay marriage in a public referendum.
1987 – First ever Rugby World Cup kicks off with New Zealand playing Italy at Eden Park in Auckland, New Zealand.
1906 – The Wright brothers are granted U.S. patent number 821,393 for their "Flying-Machine".
1864 – American Civil War: After ten weeks, the Union Army's Red River Campaign ends in failure.
1863 – American Civil War: Union forces begin the Siege of Port Hudson which lasts 48 days, the longest siege in U.S. military history.
1856 – Congressman Preston Brooks of South Carolina severely beats Senator Charles Sumner of Massachusetts with a cane in the hall of the United States Senate for a speech Sumner had made regarding Southerners and slavery.
1849 – Future U.S. President Abraham Lincoln is issued a patent for an invention to lift boats, making him the only U.S. President to ever hold a patent.
1826 – HMS Beagle departs on its first voyage.
1819 – The SS Savannah leaves port at Savannah, Georgia, United States, on a voyage to become the first steamship to cross the Atlantic Ocean.
1809 – On the second and last day of the Battle of Aspern-Essling (near Vienna, Austria), Napoleon I is repelled by an enemy army for the first time.
1807 – A grand jury indicts former Vice President of the United States Aaron Burr on a charge of treason.
1804 – The Lewis and Clark Expedition officially began as the Corps of Discovery departed from St. Charles, Missouri.
1570 – The first atlas, Theatrum Orbis Terrarum, is published with 70 maps.
1455 – Start of the Wars of the Roses: At the First Battle of St Albans, Richard, Duke of York, defeats and captures King Henry VI of England.
1999 – Camren Bicondova, American actress
1984 – Dustin Moskovitz, American entrepreneur, co-founder of Facebook
1983 – Natasha Kai, American soccer player and Olympic medalist
1982 – Apolo Ohno, American speed skater
1981 – Daniel Bryan, American wrestler
1980 – Nazanin Boniadi, Iranian-American actress
1979 – Maggie Q, American actress
1978 – Ginnifer Goodwin, American actress
1972 – Max Brooks, American author and screenwriter
1969 – Cathy McMorris Rodgers, American lawyer and politician
1966 – Johnny Gill, American singer-songwriter and producer
1965 – Jay Carney, American journalist, 29th White House Press Secretary
1962 – Brian Pillman, American football player and wrestler (d. 1997)
1957 – Lisa Murkowski, American lawyer and politician
1954 – Shuji Nakamura, Japanese-American physicist and engineer, Nobel Prize laureate
1942 – Richard Oakes, Native American civil rights activist (d. 1972)
1942 – Ted Kaczynski, American academic and mathematician turned anarchist and serial murderer (Unabomber)
1940 – Bernard Shaw, American journalist
1940 – Kieth Merrill, American filmmaker
1940 – Mick Tingelhoff American Pro Football Hall of Famer
1939 – Paul Winfield, American actor (d. 2004)
1938 – Richard Benjamin, American actor and director
1938 – Susan Strasberg, American actress (d. 1999)
1936 – George H. Heilmeier, American engineer (d. 2014)
1934 – Peter Nero, American pianist and conductor
1932 – Robert Spitzer, American psychiatrist and academic (d. 2015)
1930 – Harvey Milk, American lieutenant and politician (d. 1978)
1930 – Marisol Escobar, French-American sculptor (d. 2016)
1928 – T. Boone Pickens, American businessman
1927 – George Andrew Olah, Hungarian-American chemist and academic, Nobel Prize laureate (d. 2017)
1927 – Michael Constantine, American actor
1927 – Peter Matthiessen, American novelist, short story writer, editor, co-founded The Paris Review (d. 2014)
1922 – Quinn Martin, American screenwriter and producer (d. 1987)
1921 – George S. Hammond, American scientist (d. 2005)
1920 – Thomas Gold, Austrian-American astrophysicist and academic (d. 2004)
1917 – George Aratani, American businessman and philanthropist (d. 2013)
1914 – Sun Ra, American pianist, composer, bandleader, poet (d. 1993)
1912 – Herbert C. Brown, English-American chemist and academic, Nobel Prize laureate (d. 2004)
1908 – Horton Smith. American golfer and captain (d. 1963)
1905 – Bodo von Borries, German physicist and academic, co-invented the electron microscope (d. 1956)
1904 – Uno Lamm, Swedish electrical engineer and inventor (d. 1989)
1902 – Al Simmons, American baseball player and coach (d. 1956)
1901 – Maurice J. Tobin, American politician, 6th United States Secretary of Labor (d. 1953)
1844 – Mary Cassatt, American painter and educator (d. 1926)
1820 – Worthington Whittredge, American painter (d. 1910)
1783 – William Sturgeon, English physicist and inventor, invented the electromagnet and electric motor (d. 1850)
2017 – Nicky Hayden, American professional motorcycle racer (b. 1981)
2015 – Marques Haynes, American basketball player and coach (b. 1926)
2012 – Wesley A. Brown, American lieutenant and engineer (b. 1927)
2011 – Joseph Brooks, American director, producer, screenwriter, and composer (b. 1938)
2010 – Martin Gardner, American mathematician, cryptographer, and author (b. 1914)
2008 – Robert Asprin, American soldier and author (b. 1946)
2005 – Thurl Ravenscroft, American voice actor and singer (b. 1914)
2004 – Richard Biggs, American actor (b. 1960)
1998 – John Derek, American actor, director, and photographer (b. 1926)
1997 – Alfred Hershey, American biochemist and geneticist, Nobel Prize laureate (b. 1908)
1993 – Mieczysław Horszowski, Polish-American pianist and composer (b. 1892)
1992 – Zellig Harris, American linguist and academic (b. 1909)
1990 – Rocky Graziano, American boxer (b. 1922)
1985 – Wolfgang Reitherman, German-American animator, director, and producer (b. 1909)
1975 – Lefty Grove, American baseball player (b. 1900)